The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts.
نویسندگان
چکیده
∗ This minireview will be reprinted in the 2008 Minireview Compendium, which will be available in January, 2009. The authors’ work is currently supported by NIH Grants DA022354 and GM077430. 1 To whom correspondence should be addressed. Tel.: 734-936-5797; Fax: 734-763-4450; E-mail: [email protected] 2 The abbreviations used are: Hsp, heat shock protein; CHIP, carboxy terminus of Hsc70-interacting protein; Hop, Hsp organizing protein; TPR, tetratricopeptide repeat; GR, glucocorticoid receptor; nNOS, neuronal nitric oxide synthase; LBD, ligand binding domain. The Hsp90 Chaperone Machinery Regulates Signaling by Modulating Ligand Binding Clefts∗ William B. Pratt, Yoshihiro Morishima and Yoichi Osawa
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عنوان ژورنال:
- The Journal of biological chemistry
دوره 283 34 شماره
صفحات -
تاریخ انتشار 2008